RNA–DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-κB in human cells

Author:

Ke Weina1,Hong Enping2,Saito Renata F3,Rangel Maria Cristina3,Wang Jian4,Viard Mathias5,Richardson Melina1,Khisamutdinov Emil F6,Panigaj Martin7,Dokholyan Nikolay V4ORCID,Chammas Roger13,Dobrovolskaia Marina A2,Afonin Kirill A18ORCID

Affiliation:

1. Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, Charlotte, NC 28223, USA

2. Nanotechnology Characterization Lab., Cancer Research Technology Program, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD 21702, USA

3. Centro de Investigação Translacional em Oncologia (LIM24), Departamento de Radiologia e Oncologia, Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo, São Paulo, SP, Brazil

4. Department of Pharmacology, Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA

5. Basic Science Program, Cancer and Inflammation Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA

6. Department of Chemistry, Ball State University, Muncie, IN 47306, USA

7. Institute of Biology and Ecology, Faculty of Science, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic

8. The Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA

Funder

National Institute Of General Medical Sciences

NSF-REU and DOD-ASSURE

NanoSURE REU

National Institutes of Health

São Paulo Research Foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics

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