Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration

Author:

Borrenberghs Doortje12,Zurnic Irena2,De Wit Flore2,Acke Aline1,Dirix Lieve12,Cereseto Anna3,Debyser Zeger2,Hendrix Jelle14ORCID

Affiliation:

1. Laboratory for Photochemistry and Spectroscopy, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium

2. Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Kapucijnenvoer 33, B-3000 Leuven, Flanders, Belgium

3. Center for Integrative Biology (CIBIO), University of Trento, I-38123 Trento, Italy

4. Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre and Biomedical Research Institute (BIOMED), Hasselt University, Agoralaan C, B-3590 Diepenbeek, Belgium

Funder

Fonds Wetenschappelijk Onderzoek

KU Leuven Research Council

KU Leuven IDO program

Belgian IAP Belvir and the Methusalem program

Publisher

Oxford University Press (OUP)

Subject

Genetics

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