BET-Independent Murine Leukemia Virus Integration Is Retargeted <i>In Vivo</i> and Selects Distinct Genomic Elements for Lymphomagenesis-Reference-Cited by-同舟云学术

BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nombela Ivan¹,Michiels Martine¹,Van Looveren Dominique¹,Marcelis Lukas²³,el Ashkar Sara¹,Van Belle Siska¹,Bruggemans Anne¹^ORCID,Tousseyn Thomas²³,Schwaller Jürg⁴,Christ Frauke¹,Gijsbers Rik¹,De Rijck Jan¹,Debyser Zeger¹^ORCID

Affiliation:

1. Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Flanders, Belgium

2. Department of Imaging and Pathology, Translational Cell and Tissue Research Lab, KU Leuven, Flanders, Belgium

3. UZ Leuven, University Hospitals, Department of Pathology, KU Leuven, Flanders, Belgium

4. Department of Biomedicine, University Children’s Hospital (UKBB), University of Basel, Basel, Switzerland

Abstract

In this study, we have shown that the in vivo replication of murine leukemia virus happens independently of BET proteins, which are key host determinants involved in retroviral integration site selection. This finding opens a new research line in the discovery of alternative viral or host factors that may complement the dominant host factor.

Funder

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01478-22

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