A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance-Reference-Cited by-同舟云学术

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

Published:2018-03-10 Issue:8 Volume:46 Page:4114-4128
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Germe Thomas¹,Vörös Judit¹,Jeannot Frederic²,Taillier Thomas²,Stavenger Robert A³,Bacqué Eric²,Maxwell Anthony¹^ORCID,Bax Benjamin D¹⁴

Affiliation:

1. Department of Biological Chemistry, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, UK

2. Sanofi R&D, TSU Infectious Diseases, 1541 Avenue Marcel Mérieux, 69280 Marcy L’Etoile, France

3. Antibacterial Discovery Performance Unit, Infectious Diseases Therapy Area Unit, GlaxoSmithKline, 1250 Collegeville Road, Collegeville, PA 19426, USA

4. Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

Funder

Innovative Medicines Initiative Joint Undertaking

European Union’s Seventh Framework Programme

Wellcome Trust Investigator Award

BBSRC

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/8/4114/24783223/gky181.pdf

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