Neural network models for DMT-induced visual hallucinations

Author:

Schartner Michael M1ORCID,Timmermann Christopher23ORCID

Affiliation:

1. Département des Neurosciences Fondamentales, Université de Genève Rue Michel Servet 1 CH-1211 Geneva Switzerland

2. Department of Medicine, Centre for Psychedelic Research, Division of Brain Sciences, Imperial College London, UK The Commonwealth Building, The Hammersmith Hospital, Du Cane Road, London W12 0NN

3. Computational, Cognitive and Clinical Neuroscience Laboratory (C3NL), Department of Medicine, Imperial College London, UK Burlington Danes Building Hammersmith Hospital Du Cane Road London W12 0NN

Abstract

Abstract The regulatory role of the serotonergic system on conscious perception can be investigated perturbatorily with psychedelic drugs such as N,N-Dimethyltryptamine. There is increasing evidence that the serotonergic system gates prior (endogenous) and sensory (exogenous) information in the construction of a conscious experience. Using two generative deep neural networks as examples, we discuss how such models have the potential to be, firstly, an important medium to illustrate phenomenological visual effects of psychedelics—besides paintings, verbal reports and psychometric testing—and, secondly, their utility to conceptualize biological mechanisms of gating the influence of exogenous and endogenous information on visual perception.

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health,Neurology (clinical),Neurology,Clinical Psychology,Experimental and Cognitive Psychology

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