Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization-Reference-Cited by-同舟云学术

Gut Microbiota Features on Nursing Home Admission Are Associated With Subsequent Acquisition of Antibiotic-resistant Organism Colonization

Published:2020-06-16 Issue:12 Volume:71 Page:3244-3247
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Wang Joyce¹^ORCID,Cassone Marco²,Gibson Kristen²,Lansing Bonnie²,Mody Lona²³,Snitkin Evan S¹⁴⁵^ORCID,Rao Krishna⁵

Affiliation:

1. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

2. Division of Geriatrics and Palliative Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

3. Geriatric Research Education and Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA

4. Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, Michigan, USA

5. Division of Infectious Diseases, Department of Medicine, University of Michigan, Medical School, Ann Arbor, Michigan, USA

Abstract

Abstract Nursing home (NH) patients often acquire colonization with antibiotic-resistant organisms (AROs). We show that patients exposed to broad-spectrum antibiotics during previous hospitalizations have elevated enterococcal relative abundances on NH admission and higher risk of subsequent ARO acquisition. Our findings suggest that interventions preventing ARO spread should extend beyond NH doors.

Funder

Centers for Disease Control and Prevention

National Institutes of Health

National Institute on Aging

University of Michigan Host Microbiome Initiative Microbiome Explorers Program

Canadian Institutes of Health Research

Michigan Institute for Clinical and Health Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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