No Effect of Lactobacillus rhamnosus GG on Eradication of Colonization by Vancomycin-Resistant Enterococcus faecium or Microbiome Diversity in Hospitalized Adult Patients

Author:

Rubin Ingrid Maria Cecilia12ORCID,Mollerup Sarah1ORCID,Broholm Christa3,Knudsen Signe Boye4,Baker Adam3,Helms Morten5,Holm Mona Katrine Alberthe1,Kallemose Thomas6,Westh Henrik17,Dahl Knudsen Jenny18,Pinholt Mette1,Petersen Andreas Munk127

Affiliation:

1. Department of Clinical Microbiology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark

2. Department of Gastroenterology, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark

3. Chr. Hansen A/S, Human Health, Hoersholm, Denmark

4. Department of Clinical Microbiology, Copenhagen University Hospital, Herlev, Denmark

5. Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark

6. Clinical Research Centre, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark

7. Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

8. Department of Clinical Microbiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark

Abstract

Whereas other studies exploring the effect of L. rhamnosus in clearing VREfm from the intestine included children and adults, with a wider age range, our study consisted of a geriatric patient cohort. The natural clearance of VREfm in this study was almost 60% after 4 weeks, thus much higher than described previously.

Funder

Hvidovre University Hospital

Chr.Hansen

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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