Serum Antibody Profile of a Patient With Coronavirus Disease 2019 Reinfection

Author:

To Kelvin Kai-Wang12,Hung Ivan Fan-Ngai3,Chan Kwok-Hung1,Yuan Shuofeng1,To Wing-Kin4,Tsang Dominic Ngai-Chong5,Cheng Vincent Chi-Chung12,Chen Zhiwei1,Kok Kin-Hang1,Yuen Kwok-Yung12

Affiliation:

1. State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China

2. Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China

3. Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China

4. Department of Pathology, Princess Margaret Hospital, Hong Kong Special Administrative Region, China

5. Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region, China

Abstract

Abstract We recently reported a patient with coronavirus disease 2019 reinfection. Here, we show that serum neutralizing antibodies could be detected during the first episode but not at the presentation of the second episode. During reinfection, neutralizing antibodies and high avidity immunoglobulin G were found within 8 days after hospitalization, whereas immunoglobulin M response was absent.

Funder

Research Grants Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference13 articles.

1. Unique SARS-CoV-2 clusters causing a large COVID-19 outbreak in Hong Kong [manuscript published online ahead of print 5 August 2020];To;Clin Infect Dis,2020

2. SARS-CoV-2 infection protects against rechallenge in rhesus macaques;Chandrashekar;Science,2020

3. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study;To;Lancet Infect Dis,2020

4. High neutralizing antibody titer in intensive care unit patients with COVID-19;Liu;Emerg Microbes Infect,2020

5. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections;Long;Nat Med,2020

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