To Induce Immune Reconstitution Inflammatory Syndrome or Suppress It: The Spectrum of Mycobacterium genavense in the Antiretroviral Era

Author:

Manion Maura1ORCID,Lynn Niamh2,Pei Luxin1,Hammoud Dima A3,Laidlaw Elizabeth1,Roby Gregg1,Metzger Dorinda1,Mejia Yolanda4,Lisco Andrea1,Zelazny Adrian1,Holland Steve1,Vachon Marie-Louise5,Scherer Matthew6,Bergin Colm2,Sereti Irini1

Affiliation:

1. National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

2. St James’s Hospital, Dublin, Ireland

3. Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA

4. Leidos, Frederick, Maryland, USA

5. Centre hospitalier universitaire de Quebec–Université Laval, Quebec City, Quebec, Canada

6. Division of Infectious Diseases, Department of Internal Medicine, Columbia University Irving Medical Center, New York, New York, USA

Abstract

Abstract Mycobacterium  genavense is a challenging opportunistic pathogen to diagnose and manage in patients with human immunodeficiency virus (HIV). Persistent immunosuppression or protracted immune reconstitution inflammatory syndrome can lead to complicated clinical courses. We describe 3 cases of M. genavense in patients with HIV representing the spectrum between disease burden and strength of immune response.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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