Affiliation:
1. Department of Mycobacteriology, Statens Serum Institut,1 and
2. Department of Infectious Diseases, Hvidovre University Hospital,2Copenhagen, Denmark
Abstract
ABSTRACT
In the present study we compared the clinical presentations of patients with a clinical diagnosis of AIDS and disseminated
Mycobacterium genavense
infection (
n
= 12) with those of patients with AIDS and disseminated
M. avium
complex (MAC) infection (
n
= 24). Abdominal pain was seen more frequently in the group of patients infected with
M. genavense
than in patients infected with MAC (
P
= 0.003). Analysis of microbiological data revealed that stool specimens from patients infected with
M. genavense
were more often smear positive than stool specimens from patients infected with MAC (
P
= 0.00002). However,
M. genavense
could be cultured on solid media from only 15.4% of the stool specimens, whereas MAC could be cultured from 71.4% of the specimens. Bone marrow and liver biopsy specimens yielded growth of
M. genavense
within a reasonably short time, allowing species identification by DNA technology. Microbiological data clearly demonstrated the importance of acidic liquid medium for primary culture, the avoidance of pretreatment and the use of additives in culture, and the necessity for prolonged incubation if
M. genavense
is suspected. Susceptibility testing showed that
M. genavense
is sensitive to rifamycins, fluoroquinolones, and macrolides, whereas it is resistant to isoniazid. Susceptibility to ethambutol and clofazimine could not be evaluated. The mean survival times of patients in the two groups were similar.
Publisher
American Society for Microbiology
Cited by
52 articles.
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