Homozygosity and Linkage Disequilibrium-Reference-Cited by-同舟云学术

Homozygosity and Linkage Disequilibrium

Published:2002-04-01 Issue:4 Volume:160 Page:1707-1719
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Sabatti Chiara¹,Risch Neil²

Affiliation:

1. Department of Human Genetics and Statistics, University of California, Los Angeles, California 90095-7088

2. Department of Genetics, Stanford University, Stanford, California 94305-5120

Abstract

Abstract We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear biological interpretation, can be used to construct tests, and are standardized to allow comparison across loci and populations. They are particularly advantageous to measure linkage disequilibrium between highly polymorphic markers.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/160/4/1707/42036907/genetics1707.pdf

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