Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study-Reference-Cited by-同舟云学术

Transcriptional Analysis for Tuberculosis in Pregnant Women From the PRegnancy Associated Changes In Tuberculosis Immunology (PRACHITi) Study

Published:2022-06-10 Issue:12 Volume:75 Page:2239-2242
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Mathad Jyoti S¹,Queiroz Artur T L²³,Bhosale Ramesh⁴⁵,Alexander Mallika⁵,Naik Shilpa⁴⁵,Kulkarni Vandana⁵,Andrade Bruno B²⁶,Gupta Amita⁵⁷^ORCID

Affiliation:

1. Center for Global Health, Weill Cornell Medicine , New York, New York , USA

2. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative , Salvador , Brazil

3. Centro de Integração de Dados e Conhecimentos para Saúde, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz , Salvador , Brazil

4. Byramjee Jeejeebhoy Government Medical College–Sassoon Government Hospital , Pune , India

5. Byramjee Jeejeebhoy Government Medical College–Johns Hopkins University Clinical Trials Unit , Pune , India

6. Laboratório de Inflamação e Biomarcadores, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz , Salvador , Brazil

7. Division of Infectious Diseases, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

Abstract

Abstract A new tuberculosis (TB) diagnostic cartridge assay, which detects a 3-gene TB signature in whole blood, was not diagnostic in women with maternal TB disease in India (area under the curve [AUC] = 0.72). In a cohort of pregnant women, we identified a novel gene set for TB diagnosis (AUC = 0.97) and one for TB progression (AUC = 0.96).

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

NIAID

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac437/46399581/ciac437.pdf

Reference12 articles.

1. Risk of tuberculosis in pregnancy: a national, primary care-based cohort and self-controlled case series study;Zenner;Am J Respir Crit Care Med,2012