Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease-Reference-Cited by-同舟云学术

Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease

Published:2022-05-25 Issue:11 Volume:75 Page:2016-2018
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Riddell Anna C¹,Kele Beatrix¹,Harris Kathryn¹,Bible Jon¹,Murphy Maurice²,Dakshina Subathira²,Storey Nathaniel³,Owoyemi Dola¹,Pade Corinna⁴,Gibbons Joseph M⁴,Harrington David¹,Alexander Eliza¹,McKnight Áine⁴,Cutino-Moguel Teresa¹

Affiliation:

1. Virology Department, Division of Infection, Barts Health NHS Trust , London , United Kingdom

2. Department of Infection and Immunity, Barts Health NHS Trust , London , United Kingdom

3. Microbiology, Virology, and Infection Prevention and Control, Great Ormond Street Hospital for Children NHS Foundation Trust , London , United Kingdom

4. Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London , United Kingdom

Abstract

Abstract The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.

Funder

Rosetrees Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac409/44666867/ciac409.pdf

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3. SARS-CoV-2 prolonged infection during advanced HIV disease evolves extensive immune escape;Cele,2022