1. Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, 4057 Basel, Switzerland, 2Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tübingen, 72074 Tübingen, Germany, 3Department of Pharmacology and Toxicology, Michigan State University, MI 48824, USA and 4Biozentrum, University of Basel and Swiss Institute of Bioinformatics, 4056 Basel, Switzerland