Risk Factors for Invasive Meningococcal Disease Belonging to a Novel Urethritis Clade of Neisseria meningitidis—United States, 2013–2017

Author:

Oliver Sara E1,Retchless Adam C1,Blain Amy E1,McNamara Lucy A1,Ahrabifard Susann2,Farley Monica3,Weiss Don4,Zaremski Elizabeth5,Wang Xin1,Hariri Susan1

Affiliation:

1. Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Wisconsin Division of Public Health, Madison, Wisconsin, USA

3. Emory University School of Medicine, VA Medical Center, Atlanta, Georgia, USA

4. New York City Department of Health and Mental Hygiene, Queens, New York, USA

5. New Jersey Department of Health, Trenton, New Jersey, USA

Abstract

Abstract We describe cases of invasive meningococcal disease caused by nongroupable Neisseria meningitidis belonging to a novel phylogenetic clade associated with urethritis. Seven cases were identified, comprising 0.6% of sequenced invasive meningococcal disease isolates from 2013 to 2017. Five patients had a known or likely immunocompromising condition, including 2 with a complement deficiency.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference11 articles.

1. High risk for invasive meningococcal disease among patients receiving eculizumab (Solaris) despite receipt of meningococcal vaccine.;McNamara;MMWR,2017

2. Complement deficiency predisposes for meningitis due to nongroupable meningococci and Neisseria-related bacteria.;Fijen;Clin Infect Dis,1994

3. Invasive meningococcal disease due to nongroupable Neisseria meningitidis—Active Bacterial Core surveillance sites, 2011–2016.;McNamara;Open Forum Infect Dis,2019

4. Isolation of meningococcus from the genitourinary tract of seven patients.;Carpenter;Am J Public Health,1942

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