Invasive Meningococcal Disease due to Nongroupable Neisseria meningitidis—Active Bacterial Core Surveillance Sites, 2011

Invasive Meningococcal Disease due to Nongroupable Neisseria meningitidis—Active Bacterial Core Surveillance Sites, 2011–2016

Published:2019-04-15 Issue:5 Volume:6 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

McNamara Lucy A¹^ORCID,Potts Caelin C¹,Blain Amy¹,Topaz Nadav¹,Apostol Mirasol²,Alden Nisha B³,Petit Susan⁴,Farley Monica M⁵,Harrison Lee H⁶,Triden Lori⁷,Muse Alison⁸,Poissant Tasha⁹,Wang Xin¹,MacNeil Jessica R¹⁰

Affiliation:

1. Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

2. California Emerging Infections Program, Oakland, California

3. Emerging Infections Program, Communicable Disease Branch, Colorado Disease Control and Environmental Epidemiology Division, Denver, Colorado

4. Connecticut Department of Public Health Epidemiology Program, Hartford, Connecticut

5. Emory University School of Medicine and the Atlanta VAMC, Atlanta, Georgia

6. Departments of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

7. Emerging Infections Unit, Acute Disease Investigations and Control Section, Minnesota Department of Health, St. Paul, Minnesota

8. New York State Department of Health Emerging Infections Program, Albany, New York

9. Oregon Health Authority, Portland, Oregon

10. Office of the Director, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

Abstract We characterized 22 meningococcal disease cases due to nongroupable Neisseria meningitidis, a rare cause of invasive disease. Disease presentation and severity were similar to those for serogroupable meningococcal disease. However, 7 (32%) patients had complement deficiency or abnormal complement testing results, highlighting the importance of complement testing for nongroupable cases.

Funder

United States Centers for Disease Control and Prevention Emerging Infections

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofz190/28408541/ofz190.pdf

Reference13 articles.

1. Complement deficiency predisposes for meningitis due to nongroupable meningococci and Neisseria-related bacteria;Fijen;Clin Infect Dis,1994

2. High risk for invasive meningococcal disease among patients receiving eculizumab (Soliris) despite receipt of meningococcal vaccine;McNamara;MMWR Morb Mortal Wkly Rep,2017

3. Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus;Hoang;Clin Infect Dis,2005