Viral Load Among Vaccinated and Unvaccinated, Asymptomatic and Symptomatic Persons Infected With the SARS-CoV-2 Delta Variant

Author:

Acharya Charlotte B1,Schrom John2,Mitchell Anthea M3,Coil David A1,Marquez Carina24ORCID,Rojas Susana2,Wang Chung Yu3,Liu Jamin5,Pilarowski Genay26,Solis Leslie1,Georgian Elizabeth1,Belafsky Sheri7,Petersen Maya28ORCID,DeRisi Joseph3,Michelmore Richard1ORCID,Havlir Diane24

Affiliation:

1. Genome Center, University of California, Davis, Davis, California, USA

2. Unidos en Salud, San Francisco, California, USA

3. Chan Zuckerberg Biohub and Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, California, USA

4. Division of HIV, Infectious Disease and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA

5. Joint UCB/UCSF Bioengineering Program, University of California, Berkeley, and University of California, San Francisco, San Francisco, California, USA

6. The Public Health Company, Oakland, California, USA

7. Department of Public Health Sciences, University of California, Davis, Davis, California, USA

8. School of Public Health, University of California, Berkeley, Berkeley, California, USA

Abstract

Abstract We found no significant difference in cycle threshold values between vaccinated and unvaccinated persons infected with severe acute respiratory syndrome coronavirus 2 Delta, overall or stratified by symptoms. Given the substantial proportion of asymptomatic vaccine breakthrough cases with high viral levels, interventions, including masking and testing, should be considered in settings with elevated coronavirus disease 2019 transmission.

Funder

Chan Zuckerberg Biohub, Healthy Yolo Together, the University of California, San Francisco

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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