Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?-Reference-Cited by-同舟云学术

Time to SARS-CoV-2 PCR Clearance in Immunocompromising Conditions: Is Test-Based Removal From Isolation Necessary in Severely Immunocompromised Individuals?

Published:2021-05-20 Issue:6 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Epstein Rachel L¹^ORCID,Sperring Heather²,Hofman Melissa³,Lodi Sara⁴,White Laura F⁴,Barocas Joshua A¹,Bouton Tara C¹,Xiao Yian⁵,Hsu Heather E⁶,Miller Nancy S⁷,Linas Benjamin P¹,Marathe Jai G¹

Affiliation:

1. Section of Infectious Diseases, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

2. Center for Infectious Diseases, Boston Medical Center, Boston, Massachusetts, USA

3. Boston Medical Center, Boston, Massachusetts, USA

4. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA

5. Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

6. Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts, USA

7. Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

Abstract

Abstract To determine the association between immunosuppression and time to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) clearance, we studied 3758 adults retested following initial SARS-CoV-2 infection. Cox proportional hazards models demonstrated delayed PCR clearance with older age, multiple comorbidities, and solid organ transplant but not by degree of immunocompromise. These findings challenge current retesting practices.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Providence/Boston Center for AIDS Research

National Institute of General Medical Sciences

National Center for Advancing Translational Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofab164/37961649/ofab164.pdf