SARS-CoV-2 Polymerase Chain Reaction Cycle Threshold Trends in Patients Who Are Immunocompromised and Implications for Isolation Precautions-Reference-Cited by-同舟云学术

SARS-CoV-2 Polymerase Chain Reaction Cycle Threshold Trends in Patients Who Are Immunocompromised and Implications for Isolation Precautions

Published:2024-06-28 Issue:7 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Harris Courtney E¹^ORCID,Vaidya Vineeta²,Lan Zhou³,Klompas Michael⁴,Rhee Chanu⁴^ORCID,Baden Lindsey R⁴,Baker Meghan A⁴

Affiliation:

1. Division of Infectious Disease, Medical University of South Carolina , Charleston, South Carolina , USA

2. Infection Control Department, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

3. Center for Clinical Investigation, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

4. Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract Among 495 patients who were immunocompromised and tested positive for SARS-CoV-2, polymerase chain reaction cycle thresholds remained <33 beyond 20 days more frequently in patients with hematologic malignancies, particularly those receiving B-cell–depleting or Bruton tyrosine kinase inhibitor therapy, as compared with those with solid organ malignancy (26% vs 5%).

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae367/58363681/ofae367.pdf

Reference12 articles.

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3. Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards;Scola;Eur J Clin Microbiol Infect Dis,2020

4. Cycle threshold values and SARS-CoV-2: relationship to demographic characteristics and disease severity;Penney;J Méd Virol,2022