Exploring the Pharmacokinetics of Phenoxymethylpenicillin (Penicillin-V) in Adults: A Healthy Volunteer Study

Author:

Rawson Timothy M12ORCID,Wilson Richard C12,Moore Luke S P134,Macgowan Alasdair P5,Lovering Andrew M5,Bayliss Mark5,Kyriakides Mathew5,Gilchrist Mark12,Roberts Jason A6,Hope William W7,Holmes Alison H12

Affiliation:

1. National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK

2. Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, London, UK

3. Chelsea & Westminster NHS Foundation Trust, London, UK

4. Central London Community Healthcare NHS Trust, London, UK

5. Department of Infection Sciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK

6. Burns Trauma and Critical Care Research Centre and Centre for Translational Pharmacodynamics, The University of Queensland, Brisbane, Australia

7. Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK

Abstract

Abstract This healthy volunteer study aimed to explore phenoxymethylpenicillin (penicillin-V) pharmacokinetics (PK) to support the planning of large dosing studies in adults. Volunteers were dosed with penicillin-V at steady state. Total and unbound penicillin-V serum concentrations were determined, and a base population PK model was fitted to the data.

Funder

NIHR Imperial Biomedical Research Centre

National Institute for Health Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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