Affiliation:
1. CSL Seqirus , Kirkland, Quebec , Canada
2. FISABIO , Valencia , Spain
3. University of Maryland School of Medicine , Baltimore, Maryland , USA
4. Veradigm , Chicago, Illinois , USA
5. CSL Seqirus Netherlands B.V. , Amsterdam , the Netherlands
Abstract
Abstract
Background
The mammalian cell-based quadrivalent inactivated influenza vaccine (IIV4c) has advantages over egg-based quadrivalent inactivated influenza vaccine (IIV4e), as production using cell-derived candidate viruses eliminates the opportunity for egg adaptation. This study estimated the relative vaccine effectiveness (rVE) of IIV4c versus IIV4e in preventing cardiorespiratory hospitalizations during the 2019–2020 US influenza season.
Methods
We conducted a retrospective cohort study using electronic medical records linked to claims data of US individuals aged 18–64 years. We assessed rVE against cardiorespiratory hospitalizations and against subcategories of this outcome, including influenza, pneumonia, myocardial infarction and ischemic stroke, and respiratory hospitalizations. We used a doubly robust inverse probability of treatment weighting and logistic regression model to obtain odds ratios (ORs; odds of outcome among IIV4c recipients/odds of outcome among IIV4e recipients) adjusted for age, sex, race, ethnicity, geographic region, vaccination week, health status, frailty, and healthcare resource utilization. rVE was calculated as 100(1 − ORadjusted).
Results
In total, 1 491 097 individuals (25.2%) received IIV4c, and 4 414 758 (74.8%) received IIV4e. IIV4c was associated with lower odds of cardiorespiratory (rVE, 2.5% [95% confidence interval, 0.9%–4.1%]), respiratory (3.7% [1.5%–5.8%]), and influenza (9.3% [0.4%–17.3%]) hospitalizations among adults 18–64 years of age. No difference was observed for the other outcomes.
Conclusions
This real-world study conducted for the 2019–2020 season demonstrated that vaccination with IIV4c was associated with fewer cardiorespiratory, respiratory, and influenza hospitalizations compared with IIV4e.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献