Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults-Reference-Cited by-同舟云学术

Respiratory Syncytial Virus Infection: Its Propensity for Bacterial Coinfection and Related Mortality in Elderly Adults

Published:2020-11-12 Issue:12 Volume:7 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Godefroy Raphael¹²,Giraud-gatineau Audrey¹³,Jimeno Marie-Thérèse⁴,Edouard Sophie¹³,Meddeb Line¹³,Zandotti Christine¹⁵,Chaudet Hervé¹³,Colson Philippe¹²,Raoult Didier¹²,Cassir Nadim¹²^ORCID

Affiliation:

1. IHU-Méditerranée Infection, Marseille, France

2. Aix-Marseille Univ, IRD, AP-HM, MEPHI, Marseille, France

3. UMR VITROME, Aix-Marseille University, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France

4. Service de l’Information Médicale, Hôpital de la Timone, Marseille, France

5. Laboratoire de Virologie IHU Méditerranée Infection, CHU Timone, UMR190-Emergence des Pathologies Virales, Marseille, France

Abstract

Abstract Respiratory syncytial virus (RSV) is an increasingly recognized cause of acute respiratory infection (ARI) in adults. We compared the crude in-hospital mortality of patients with RSV infection alone with that of patients with RSV–bacterial coinfection. Overall, 12 144 hospitalized patients with ARI were screened for RSV detection by polymerase chain reaction between February 2014 and April 2019. In total, 701 (5.8%) had a positive RSV result, including 85 (12.1%) with bacterial coinfection. RSV–bacterial coinfection was associated with an increase in crude in-hospital mortality in patients >65 years old (hazard ratio, 2.94; 95% CI, 1.30–6.60; P = .010). Optimized prevention and management strategies to reduce this burden are needed.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofaa546/34266332/ofaa546.pdf

Reference15 articles.

1. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016;GBD 2016 Lower Respiratory Infections Collaborators;Lancet Infect Dis,2018

2. Systematic review on respiratory syncytial virus epidemiology in adults and the elderly in Latin America;Ali;Int J Infect Dis,2020

3. Respiratory syncytial virus infection in elderly and high-risk adults;Falsey;N Engl J Med,2005

4. Epidemiology and clinical characteristics of respiratory syncytial virus infections among children and adults in Mexico;Gamiño-Arroyo;Influenza Other Respir Viruses,2017

5. Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France;Loubet;Clin Microbiol Infect,2017

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