From Forgotten Pathogen to Target for New Vaccines: What Clinicians Need to Know about Respiratory Syncytial Virus Infection in Older Adults

Author:

Boattini Matteo123ORCID,Almeida André45ORCID,Comini Sara6,Bianco Gabriele127ORCID,Cavallo Rossana12,Costa Cristina12ORCID

Affiliation:

1. Microbiology and Virology Unit, University Hospital Città della Salute e della Scienza di Torino, 10126 Turin, Italy

2. Department of Public Health and Paediatrics, University of Torino, 10126 Turin, Italy

3. Lisbon Academic Medical Centre, 1649-028 Lisbon, Portugal

4. Department of Internal Medicine 4, Centro Hospitalar Universitário de Lisboa Central, Centro Clínico Académico de Lisboa, 1169-024 Lisbon, Portugal

5. NOVA Medical School, Universidade Nova de Lisboa, Centro Clínico Académico de Lisboa, 1169-056 Lisbon, Portugal

6. Operative Unit of Clinical Pathology, Carlo Urbani Hospital, 60035 Jesi, Italy

7. Department of Experimental Medicine, University of Salento, Via Provinciale Monteroni n. 165, 73100 Lecce, Italy

Abstract

Respiratory syncytial virus (RSV) is increasingly recognized as being implicated in acute illness in older adults, with a significant weight in hospitalizations for respiratory illness and death. By means of a best-evidence review, this paper aims to investigate whether RSV can be considered a forgotten pathogen in older patients, looking at trends in the literature volume and exploring possible epidemiological and clinical features underlying the focus given to it. We then present an assessment of its disease burden and present and future strategies for its reduction, particularly in light of the recent availability of new vaccines.

Funder

EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases

Publisher

MDPI AG

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