Evidence of Failure of Oral Third-Generation Cephalosporin Treatment for Shigella sonnei Infection

Author:

Collins Jennifer P12,Friedman Cindy R2,Birhane Meseret G2,Karp Beth E2,Osinski Anthony3,Montgomery Mary W4,Thomas Deepam5,Barkley Jonathan6,Sanchez Martha C7,Hanna Samir8,Adediran Azizat A9,Chen Jessica C9,Caidi Hayat9,Francois Watkins Louise2

Affiliation:

1. Epidemic Intelligence Service, Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

3. Massachusetts Department of Public Health, Bureau of Infectious Disease and Laboratory Sciences, Boston, Massachusetts, USA

4. Brigham and Women’s Hospital, Division of Infectious Diseases, Boston, Massachusetts, USA

5. New Jersey Department of Health, Communicable Disease Service, Trenton, New Jersey, USA

6. Rhode Island Department of Health, Center for Acute Infectious Disease Epidemiology, Providence, Rhode Island, USA

7. Brown Medicine, Division of Infectious Diseases, Providence, Rhode Island, USA

8. Tennessee Department of Health, Communicable and Environmental Diseases and Emergency Preparedness, Nashville, Tennessee, USA

9. Enteric Diseases Laboratory Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Abstract

Abstract In 2017, state health departments notified the Centers for Disease Control and Prevention about 4 patients with shigellosis who experienced persistent illness after treatment with oral third-generation cephalosporins. Given increasing antibiotic resistance among Shigella, these cases highlight the need to evaluate the efficacy of oral cephalosporins for shigellosis.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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