The evolution and international spread of extensively drug resistant Shigella sonnei-Reference-Cited by-同舟云学术

The evolution and international spread of extensively drug resistant Shigella sonnei

Published:2022-09-15 Issue: Volume: Page:
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Author:

Mason Lewis¹^ORCID,Greig David²,Cowley Lauren³,Partridge Sally⁴^ORCID,Martinez Elena⁵,Blackwell Grace⁶,Chong Charlotte⁷,De Silva Malaka⁷,Bengtsson Rebecca⁸,Draper Jenny⁹^ORCID,Ginn Andrew⁹,Sandaradura Indy⁶^ORCID,Sim Eby⁹,Iredell Jonathan⁴,Sintchenko Vitali⁴^ORCID,Ingle Danielle¹⁰^ORCID,Howden Benjamin¹¹^ORCID,Lefevre Sophie¹²^ORCID,Njamkepo Elisabeth¹²,Weill François-Xavier¹²^ORCID,Ceyssens Pieter-Jan¹³,Jenkins Claire²,Baker Kate⁸^ORCID

Affiliation:

1. NIHR HPRU in Gastrointestinal Infections at University of Liverpool

2. Gastrointestinal and Food Safety (One Health) Division

3. University of Bath

4. University of Sydney

5. Institute of Clinical Pathology and Medical Research

6. New South Wales Health Pathology

7. Clinical Infection, Microbiology, and Immunology

8. University of Liverpool

9. NSW Health Pathology

10. The University of Melbourne

11. The University of Melbourne at the Doherty Institute for Infection and Immunity; Victorian Infectious Disease Service, The Royal Melbourne Hospital, Peter Doherty Institute for Infection & Immunity

12. Institut Pasteur

13. Sciensano

Abstract

Abstract Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common and can include resistance to the World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum β-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, natural history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a common, low fitness-cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.

Publisher

Research Square Platform LLC

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