Plasma and Cerebrospinal Fluid Therapeutic Drug Monitoring of Ceftolozane and Tazobactam During Treatment of Multidrug-Resistant Pseudomonas aeruginosa Meningitis

Author:

McCreary Erin K1ORCID,Byers Karin E1,Fernandes Carolyn1,Kline Ellen G1,Nicolau David P2,Shields Ryan K1

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

2. Center for Anti-Infective Research and Development, Hartford, Connecticut, USA

Abstract

Abstract We report a case of multidrug-resistant Pseudomonas aeruginosa meningitis treated with ceftolozane-tazobactam with concomitant therapeutic drug monitoring of plasma and cerebral spinal fluid. The data suggest that ceftolozane-tazobactam may be an option for select central nervous system infections; however, treatment decisions should be interpreted on a case-by-case basis.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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