Affiliation:
1. Harvard Medical School, head of the Genomics and Bioinformatics Hub at Brigham and Women’s Hospital
2. SUNY Upstate Medical University
3. Department of Biostatistics, Virginia Commonwealth University
Abstract
Abstract
In the last decade, massive omics datasets have been generated for human brain research. It is evolving so fast that a timely update is urgently needed. In this review, we summarize the main multi-omics data resources for the human brains of both healthy controls and neuropsychiatric disorders, including schizophrenia, autism, bipolar disorder, Alzheimer’s disease, Parkinson’s disease, progressive supranuclear palsy, etc. We also review the recent development of single-cell omics in brain research, such as single-nucleus RNA-seq, single-cell ATAC-seq and spatial transcriptomics. We further investigate the integrative multi-omics analysis methods for both tissue and single-cell data. Finally, we discuss the limitations and future directions of the multi-omics study of human brain disorders.
Publisher
Oxford University Press (OUP)
Subject
Genetics,Molecular Biology,Biochemistry,General Medicine
Cited by
17 articles.
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