Brain cell type–specific enhancer–promoter interactome maps and disease - risk association

Author:

Nott Alexi1ORCID,Holtman Inge R.12ORCID,Coufal Nicole G.34ORCID,Schlachetzki Johannes C. M.1ORCID,Yu Miao5,Hu Rong5ORCID,Han Claudia Z.1,Pena Monique3,Xiao Jiayang3ORCID,Wu Yin3,Keulen Zahara3,Pasillas Martina P.1ORCID,O’Connor Carolyn6ORCID,Nickl Christian K.1,Schafer Simon T.3ORCID,Shen Zeyang17ORCID,Rissman Robert A.89,Brewer James B.8,Gosselin David110ORCID,Gonda David D.11ORCID,Levy Michael L.11,Rosenfeld Michael G.12,McVicker Graham13ORCID,Gage Fred H.2ORCID,Ren Bing413,Glass Christopher K.114ORCID

Affiliation:

1. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

2. Section Molecular Neurobiology, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, the Netherlands.

3. Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

4. Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

5. Ludwig Institute for Cancer Research, La Jolla, CA 92093, USA.

6. Flow Cytometry Core Facility, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

7. Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.

8. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

9. Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.

10. Centre de Recherche du Centre Hospitalier Universitaire de Québec–Université Laval, Département de Médecine Moléculaire, Faculté de Médecine, Université Laval, Québec G1V 4G2, Canada.

11. Department of Neurosurgery, University of California, San Diego–Rady Children’s Hospital, San Diego, CA 92123, USA.

12. Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

13. The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

14. Department of Cellular and Molecular Medicine, Center for Epigenomics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.

Abstract

Linking enhancers to disease Enhancers are genomic regions that regulate gene expression, sometimes in a cell-dependent manner. However, most of our knowledge of human brain cell–type enhancers derives from studies of bulk human brain tissue. Nott et al. examined chromatin and promoter activity in cell nuclei isolated from human brains. Genetic variants associated with brain traits and disease showed cell-specific patterns of enhancer enrichment. These data indicate that Alzheimer's disease is regulated by genetic variants within microglial cells, whereas psychiatric diseases tend to affect neurons. Science , this issue p. 1134

Funder

National Institutes of Health

National Institute on Aging

National Cancer Institute

Netherlands Organization for Scientific Research

Engman Foundation

American Heart Association / Allen Initiative in Brain Health and Cognitive Impairment

JPB Foundation

Cure Alzheimer's Fund

Alzheimer's Association

Cancer Research Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3