Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC

Author:

Kisby Glen E1,Eriksen Jason L2,Chlebowski Anna C1,Spencer Peter S3

Affiliation:

1. Pharmacology, Western University for Health Sciences, Lebanon, Oregon, USA

2. Pharmacology, University of Houston, Houston, Texas, USA

3. Neurology, School of Medicine and Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, Oregon, USA

Funder

U.S. National Institute for Environmental Health Sciences

U.S. Army Medical Research and Materiel Command

U.S. National Institute for Neurological and Communicative Disorders and Stroke

NIH

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Neurology,General Medicine,Pathology and Forensic Medicine

Reference16 articles.

1. Expression of mutant ubiquitin and proteostasis impairment in Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex brains;Verheijen;J Neuropathol Exp Neurol,2020

2. Activation of the unfolded protein response and proteostasis disturbance in parkinsonism-dementia of Guam;Verheijen;J Neuropathol Exp Neurol,2020

3. Deposition of mutant ubiquitin in parkinsonism-dementia complex of Guam;Verheijen;Acta Neuropathol Commun,2017

4. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?;Kisby;Int J Environ Res Public Health,2011

5. Kampō medicine and Muro disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex;Spencer;eNeurologicalSci,2020

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