Opportunities and Challenges in the Development of Experimental Drug Combinations for Cancer-Reference-Cited by-同舟云学术

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Opportunities and Challenges in the Development of Experimental Drug Combinations for Cancer

Published:2011-07-15 Issue:16 Volume:103 Page:1222-1226
ISSN:0027-8874
Container-title:JNCI Journal of the National Cancer Institute
language:en
Short-container-title:JNCI Journal of the National Cancer Institute

Author:

W. Humphrey R.,M. Brockway-Lunardi L.,T. Bonk D.,Dohoney K. M.,Doroshow J. H.,Meech S. J.,Ratain M. J.,Topalian S. L.,M. Pardoll D.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

http://academic.oup.com/jnci/article-pdf/103/16/1222/7672885/djr246.pdf

Reference23 articles.

1. Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

2. Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

3. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

4. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

5. Dose-escalation models for combination phase I trials in oncology

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