Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K

Author:

Villanueva Jessie,Vultur Adina,Lee John T.,Somasundaram Rajasekharan,Fukunaga-Kalabis Mizuho,Cipolla Angela K.,Wubbenhorst Bradley,Xu Xiaowei,Gimotty Phyllis A.,Kee Damien,Santiago-Walker Ademi E.,Letrero Richard,D'Andrea Kurt,Pushparajan Anitha,Hayden James E.,Brown Kimberly Dahlman,Laquerre Sylvie,McArthur Grant A.,Sosman Jeffrey A.,Nathanson Katherine L.,Herlyn Meenhard

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference44 articles.

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2. Mcl-1 is required for melanoma cell resistance to anoikis;Boisvert-Adamo;Mol. Cancer Res.,2009

3. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma;Bollag;Nature,2010

4. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer;Carracedo;J. Clin. Invest.,2008

5. The type I insulin-like growth factor receptor pathway: a key player in cancer therapeutic resistance;Casa;Front. Biosci.,2008

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