Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46-Reference-Cited by-同舟云学术

Trp-Trp acts as a multifunctional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46

Published:2021-04-12 Issue:6 Volume:85 Page:1526-1529
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Ojiro Ichie¹,Nishio Hiromi¹,Yamazaki-Ito Toyomi¹²,Nakano Shogo¹²,Ito Sohei¹²,Toyohara Yoshikazu³,Hiramoto Tadahiro³,Terada Yuko¹²^ORCID,Ito Keisuke¹²^ORCID

Affiliation:

1. Department of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan

2. School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan

3. Corporate Research and Development Division, Takasago International Corporation, Hiratsuka, Kanagawa, Japan

Abstract

ABSTRACT Many functional food ingredients activate human bitter taste receptors (hTAS2Rs). In this study, A novel inhibitor, Trp-Trp, for hTAS2R14 was identified by searching for the agonist peptide's analogs. Trp-Trp also inhibited hTAS2R16, hTAS2R43, and hTAS2R46, which share the same agonists with hTAS2R14. The multifunctional characteristic of Trp-Trp is advantageous for use as bitterness-masking agents in functional foods.

Funder

Council for Science, Technology and Innovation

Cross-ministerial Strategic Innovation Promotion Program

Technologies for creating next-generation agriculture, forestry and fisheries

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbab061/37904511/zbab061.pdf

Reference20 articles.