Selective IL-23 Inhibition by Risankizumab Modulates the Molecular Profile in the Colon and Ileum of Patients With Active Crohn’s Disease: Results From a Randomised Phase II Biopsy Sub-study

Author:

Visvanathan Sudha1,Baum Patrick2,Salas Azucena3,Vinisko Richard1,Schmid Ramona2,Grebe Kristie M4,Davis Justin W5,Wallace Kori5,Böcher Wulf O6,Padula Steven J6,Fine Jay S1,Panés Julián3

Affiliation:

1. Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA

2. Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

3. Hospital Clinic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain

4. AbbVie Inc., Worcester, MA, USA

5. AbbVie Inc., North Chicago, IL, USA

6. Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany

Funder

Boehringer Ingelheim

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Reference33 articles.

1. Crohn’s disease;Baumgart;Lancet,2012

2. Targeting IL-17 and TH17 cells in chronic inflammation;Miossec;Nat Rev Drug Discov,2012

3. IL-23: a master regulator in Crohn disease;Neurath;Nat Med,2007

4. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene;Duerr;Science,2006

5. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease;Geremia;J Exp Med,2011

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