Author:
Krueger James G.,Eyerich Kilian,Kuchroo Vijay K.,Ritchlin Christopher T.,Abreu Maria T.,Elloso M. Merle,Fourie Anne,Fakharzadeh Steven,Sherlock Jonathan P.,Yang Ya-Wen,Cua Daniel J.,McInnes Iain B.
Abstract
Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases (IMIDs), including psoriasis, psoriatic arthritis, and inflammatory bowel disease. We review IL-23 biology, IL-23 signaling in IMIDs, and the effect of IL-23 inhibition in treating these diseases. We propose studies to advance IL-23 biology and unravel differences in response to anti–IL-23 therapy. Experimental evidence generated from these investigations could establish a novel molecular ontology centered around IL-23–driven diseases, improve upon current approaches to treating IMIDs with IL-23 inhibition, and ultimately facilitate optimal identification of patients and, thereby, outcomes.
Cited by
5 articles.
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