Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Disease Outcome and Response to Therapy-Reference-Cited by-同舟云学术

Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Disease Outcome and Response to Therapy

Published:2021-03-17 Issue:9 Volume:15 Page:1431-1442
ISSN:1873-9946
Container-title:Journal of Crohn's and Colitis
language:en
Short-container-title:

Author:

Verstockt Bram¹²^ORCID,Noor Nurulamin M³⁴^ORCID,Marigorta Urko M⁵⁶,Pavlidis Polychronis⁷⁸,Deepak Parakkal⁹^ORCID,Ungaro Ryan C¹⁰,Fiocchi Claudio¹¹,Torres Joana¹²,Scharl Michael¹³,

Affiliation:

1. University Hospitals Leuven Department of Gastroenterology and Hepatology, KU Leuven, Leuven, Belgium

2. KU Leuven Department of Chronic Diseases and Metabolism, Translational Research Center for Gastrointestinal Disorders [TARGID], Leuven, Belgium

3. Department of Gastroenterology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK

4. Medical Research Council Clinical Trials Unit, University College London, London, UK

5. Integrative Genomics Lab, Center for Cooperative Research in Biosciences [CIC bioGUNE], Basque Research and Technology Alliance [BRTA], Derio, Spain

6. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

7. Department of Gastroenterology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

8. School of Immunology and Microbial Sciences, King’s College London, London, UK

9. Inflammatory Bowel Diseases Center, Washington University in Saint Louis School of Medicine, St Louis, MO, USA

10. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

11. Department of Inflammation & Immunity, Lerner Research Institute, and Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA

12. Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Portugal

13. Department of Gastroenterology and Hepatology, University Hospital Zürich, Switzerland

Abstract

Abstract Inflammatory bowel diseases [IBD] are a heterogeneous spectrum with two extreme phenotypes, Crohn’s disease [CD] and ulcerative colitis [UC], which both represent numerous phenotypical variations. Hence, we should no longer approach all IBD patients similarly, but rather aim to rethink clinical classifications and modify treatment algorithms to usher in a new era of precision medicine in IBD. This scientific ECCO workshop aims to provide a state-of-the-art overview on prognostic and predictive markers, shed light on key questions in biomarker development, propose best practices in IBD biomarker development [including trial design], and discuss the potential for multi-omic data integration to help drive further advances to make precision medicine a reality in IBD.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,General Medicine

Link

http://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjab050/40352556/jjab050.pdf

Reference115 articles.

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3. Results of the seventh;Fiocchi;J Crohns Colitis,2021