Chronic Systemic Symptoms in Head and Neck Cancer Patients

Author:

Murphy Barbara A1,Wulff-Burchfield Elizabeth1,Ghiam Michael2,Bond Stewart M3,Deng Jie4

Affiliation:

1. Department of Medicine and Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN

2. Vanderbilt University School of Medicine, Nashville, TN

3. William F. Connell School of Nursing, Boston College, Boston, MA

4. School of Nursing, University of Pennsylvania, Philadelphia PA

Abstract

AbstractThe systemic effects and manifestations of disease and treatment have been of interest for millennium. Until recently, basic and clinical research is just now reaching a watershed. Systemic symptoms usually do not occur in isolation but rather in clusters; however, much of the cutting-edge research pertaining to the etiology, mechanism, manifestations, and moderators of systemic symptoms in humans has been directed at individual symptoms, thus creating silos of knowledge. Breaching these silos and bridging the knowledge from disparate arenas of investigation to build a comprehensive depiction of acute and chronic systemic symptoms has been a challenge. In addition, much of the recent work in systemic symptoms has been conducted in the setting of nonmalignant disease. The degree to which the findings from other chronic disease processes can be translated into the oncologic realm is unknown. This article will explore inflammation as a major contributing factor to systemic symptoms and sickness behavior, discuss the most common manifestations in cancer survivors, and, where available, discuss specific data pertaining to head and neck cancer survivors.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology,General Medicine

Reference123 articles.

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