Recent advances in cancer therapy‐associated oral mucositis

Author:

Abdalla‐Aslan Ragda12ORCID,Keegan Rebeca3,Zadik Yehuda4ORCID,Yarom Noam56,Elad Sharon7

Affiliation:

1. Department of Oral and Maxillofacial Surgery Rambam Health Care Campus Haifa Israel

2. Ruth and Bruce Rappaport Faculty of Medicine Technion‐Israel Institute of Technology Haifa Israel

3. General Dentistry, Eastman Institute for Oral Health University of Rochester Medical Center Rochester New York USA

4. Department of Oral Medicine, and Saligman Clinics, Faculty of Dental Medicine The Hebrew University of Jerusalem, Hadassah Medical Center Jerusalem Israel

5. Oral Medicine Unit Sheba Medical Center Tel Hashomer Israel

6. The Maurice and Gabriela Goldschleger School of Dental Medicine Faculty of Health and medical sciences Tel Aviv University Tel Aviv Israel

7. Oral Medicine, Eastman Institute for Oral Health University of Rochester Medical Center Rochester New York USA

Abstract

AbstractOral mucositis (OM) is a common and debilitating toxicity of cancer treatments – chemotherapy, radiotherapy, hematopoietic cell transplant, or combinations. OM is associated with severe oral pain and has negative impacts on patient function and quality of life. Additionally, OM has accompanying systemic complications that may have critical implications. These local and systemic consequences can alter cancer treatment, and add an economic burden. This review covers the clinical presentation and course of OM, differential diagnosis, clinical and economic impacts, pathogenesis, risk factors, assessment measures, biomarkers and prediction of OM, management, research advances in the development of new drugs and treatments, and big data.

Publisher

Wiley

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