A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium

Author:

,Suo Jinlong1ORCID,Gan Yibo2,Xie Yangli3,Xu Shuqin4,Wang Jianfang5,Chen Di6,Chen Lin3,Deng Lianfu7,Feng Shiqing8,Han Jingdong Jackie9,Jiang Qing10,Lei Guanghua11ORCID,Liu Peng2,Luo Xianghang12,Ma Xin13,Qu Jing14,Song Chunli15,Tang Peifu16,Tang Tingting17,Wang Sijia18,Wei Xiaochun19,Wu Chengtie20,Xiao Guozhi21,Yang Liu2223,Zhang Licheng16,Zhang Weiqi24ORCID,Zhang Zhenlin4ORCID,Liu Guang-Hui25ORCID,Zhang Changqing1,Pei Gang26,Luo Jian27,Yue Rui5,Zou Weiguo128

Affiliation:

1. Department of Orthopedic Surgery, Institute of Microsurgery on Extremities, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China

2. State Key Laboratory of Trauma and Chemical Poisoning, Department of Spine Surgery, Center of Orthopedics, Daping Hospital, Army Medical University (Third Military Medical University) , Chongqing , China

3. State Key Laboratory of Trauma and Chemical Poisoning, Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair (CBMR), Daping Hospital, Army Medical University (Third Military Medical University) , Chongqing , China

4. Department of Osteoporosis and Bone Diseases, Shanghai Clinical Research Center of Bone Disease, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China

5. Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University , Shanghai , China

6. Research Center for Computer-Aided Drug Discovery, Faculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences , Shenzhen , China

7. Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Department of Orthopaedics, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China

8. Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University , Jinan , China

9. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University , Beijing , China

10. State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Drum Tower Hospital affiliated to Medical School of Nanjing University , Nanjing , China

11. Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Hunan Key Laboratory of Joint Degeneration and Injury, Department of Orthopaedics, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , China

12. Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Department of Endocrinology, Endocrinology Research Center, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , China

13. Department of Orthopaedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai , China

14. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, Institute for Stem Cell and Regenerative Medicine, University of Chinese Academy of Sciences , Beijing , China

15. Beijing Key Laboratory of Spinal Disease, Department of Orthopedics, Engineering Research Center of Bone and Joint Precision Medicine, Peking University Third Hospital , Beijing , China

16. Department of Orthopaedic Trauma, the Fourth Medical Center, National Clinical Research Center for Orthopaedics & Sports Rehabilitation in China, Chinese PLA General Hospital , Beijing , China

17. Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China

18. CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai , China

19. Shanxi Key Laboratory of Bone and Soft Tissue Injury Repair, Department of Orthopedics, the Second Hospital of Shanxi Medical University , Taiyuan , China

20. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai , China

21. Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, Department of Biochemistry, School of Medicine, Southern University of Science and Technology , Shenzhen , China

22. Institute of Orthopedic Surgery, Xijing Hospital, The Fourth Military Medical University , Xi’an, Shaanxi , China

23. Medical Research Institute, Northwestern Polytechnical University , Xi’an , China

24. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing , China

25. State Key Laboratory of Membrane Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing , China

26. Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University , Shanghai , China

27. Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine , Shanghai , China

28. State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences , Shanghai, 200031 , China

Abstract

Abstract The skeleton is an important structural and metabolic organ in human body, while aging is the physiological basis for degenerative skeletal diseases. China has the largest aging population in the world and faces great challenges in preventing and managing diseases related to skeletal aging. To address these challenges, the Aging China Biomarkers Consortium (ABC) has reached an expert consensus on biomarkers of skeletal aging by synthesizing the literature and insights from scientists and clinicians. The consensus provides a comprehensive assessment of biomarkers associated with skeletal aging and proposes a systematic framework that categorizes biomarkers into three dimensions, namely, functional, structural, and humoral dimensions. Within each dimension, the ABC recommended clinical and evidential research-based biomarkers for physiological aging and degenerative pathologies of the skeleton. This expert consensus aims to lay the foundation for future studies to assess the prediction, diagnosis, early warning, and treatment of diseases associated with skeletal aging, with the ultimate goal of improving the skeletal health of elderly populations in China and around the world.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Strategic Priority Research Program of the Chinese Academy of Science

CAS Project for Young Scientists in Basic Research

Publisher

Oxford University Press (OUP)

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