A biomarker framework for liver aging: the Aging Biomarker Consortium consensus statement

Author:

,Jiang Mengmeng12,Zheng Zhuozhao3,Wang Xuan4,Chen Yanhao5,Qu Jing6,Ding Qiurong5,Zhang Weiqi7ORCID,Liu You-Shuo8,Yang Jichun9,Tang Weiqing10,Hou Yunlong11,He Jinhan12,Wang Lin13,Huang Pengyu14,Li Lin-Chen15,He Zhiying16,Gao Qiang17,Lu Qian418,Wei Lai4,Wang Yan-Jiang19,Ju Zhenyu20,Fan Jian-Gao21,Ruan Xiong Zhong22,Guan Youfei23,Liu Guang-Hui1224ORCID,Pei Gang25,Li Jian10ORCID,Wang Yunfang4151826

Affiliation:

1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

2. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

3. Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University , Beijing 102218 , China

4. Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University , Beijing 102218 , China

5. CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , Shanghai 200031 , China

6. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences , Beijing 100101 , China

7. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation , Beijing 100101 , China

8. Department of Geriatrics, the Second Xiangya Hospital, and the Institute of Aging and Geriatrics, Central South University , Changsha 410011 , China

9. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center , Beijing 100191 , China

10. The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission , Beijing 100730 , China

11. Yiling Pharmaceutical Academician Workstation , Shijiazhuang 050035 , China

12. Department of Pharmacy, West China Hospital of Sichuan University , Chengdu 610041 , China

13. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University , Xi’an 710032 , China

14. State Key Laboratory of Advanced Medical Materials and Devices, Engineering Research Center of Pulmonary and Critical Care Medicine Technology and Device (Ministry of Education), Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College , Tianjin 300192 , China

15. Clinical Translational Science Center, Beijing Tsinghua Changgung Hospital, Tsinghua University , Beijing 102218 , China

16. Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai Engineering Research Center of Stem Cells Translational Medicine , Shanghai 200092 , China

17. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University , Shanghai 200032 , China

18. Key Laboratory of Digital Intelligence Hepatology (Ministry of Education), School of Clinical Medicine, Tsinghua University , Beijing 102218 , China

19. Department of Neurology, Daping Hospital, Third Military Medical University , Chongqing 400042 , China

20. Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University , Guangzhou 510632 , China

21. Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200092 , China

22. Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University , Chongqing 400016 , China

23. Advanced Institute for Medical Sciences, Dalian Medical University , Dalian 116044 , China

24. University of Chinese Academy of Sciences , Beijing 100049 , China

25. Collaborative Innovation Center for Brain Science, School of Life Science and Technology, Tongji University , Shanghai 200092 , China

26. Research Unit of Precision Hepatobiliary Surgery Paradigm, Chinese Academy of Medical Sciences , Beijing 102218 , China

Abstract

Abstract In human aging, liver aging per se not only increases susceptibility to liver diseases but also increases vulnerability of other organs given its central role in regulating metabolism. Total liver function tends to be well maintained in the healthy elderly, so liver aging is generally difficult to identify early. In response to this critical challenge, the Aging Biomarker Consortium of China has formulated an expert consensus on biomarkers of liver aging by synthesizing the latest scientific literature, comprising insights from both scientists and clinicians. This consensus provides a comprehensive assessment of biomarkers associated with liver aging and presents a systematic framework to characterize these into three dimensions: functional, imaging, and humoral. For the functional domain, we highlight biomarkers associated with cholesterol metabolism and liver-related coagulation function. For the imaging domain, we note that hepatic steatosis and liver blood flow can serve as measurable biomarkers for liver aging. Finally, in the humoral domain, we pinpoint hepatokines and enzymatic alterations worthy of attention. The aim of this expert consensus is to establish a foundation for assessing the extent of liver aging and identify early signs of liver aging-related diseases, thereby improving liver health and the healthy life expectancy of the elderly population.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

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