Emergence of hybrid airway neutrophils with increased mitochondrial metabolism and low inflammatory response in neutrophilic asthma: evidence supporting targeting inhibition of neutrophil glycolysis in this asthma sub-group

Author:

Yang Y1,Li H2ORCID,Liu P3,Zhang X2,Wang Q1,Li H4,Cui N1,Tian X5,Long Y1,He H1,Su L1

Affiliation:

1. Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science , Beijing 100730, China

2. School of Medicine, Tsinghua University , Beijing 100084, China

3. Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100730, China

4. 4+4 Medical Doctor Program, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100730, China

5. Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100730, China

Funder

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences

CAMS Innovation Fund for Medical Sciences

National High-Level Hospital Clinical Research Fouding

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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