A ‘three-pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

Author:

Hwang Peter M.1,Li Chengjun2,Morra Massimo3,Lillywhite Jennifer2,Muhandiram D.Ranjith14,Gertler Frank5,Terhorst Cox3,Kay Lewis E.146,Pawson Tony47,Forman-Kay Julie D.18,Li Shun-Cheng2

Affiliation:

1. Department of Biochemistry, University of Toronto; Toronto Ontario M5S 1A8 Canada

2. Department of Biochemistry, Faculty of Medicine and Dentistry, University of Western Ontario; London Ontario N6A 5C1 Canada

3. Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School; Boston MA 02215 USA

4. Department of Molecular and Medical Genetics, University of Toronto; Toronto Ontario M5S 1A8 Canada

5. Department of Biology, Massachusetts Institute of Technology; 77 Massachusetts Avenue Cambridge MA 02139 USA

6. Department of Chemistry, University of Toronto; Toronto Ontario M5S 1A8 Canada

7. Samuel Lunenfeld Research Institute, Mt Sinai Hospital; Toronto Ontario M5G 1X5 Canada

8. Program in Structural Biology and Biochemistry, The Hospital for Sick Children; Toronto Ontario M5G 1X8 Canada

Publisher

Wiley

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Molecular Biology,General Neuroscience

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