Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains-Reference-Cited by-同舟云学术

Human Immunization With a Polymorphic Malaria Vaccine Candidate Induced Antibodies to Conserved Epitopes That Promote Functional Antibodies to Multiple Parasite Strains

Published:2018-03-23 Issue:1 Volume:218 Page:35-43
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Feng Gaoqian¹²,Boyle Michelle J¹,Cross Nadia¹,Chan Jo-Anne¹,Reiling Linda¹,Osier Faith¹³⁴,Stanisic Danielle I⁵,Mueller Ivo⁶,Anders Robin F⁷,McCarthy James S⁸,Richards Jack S¹²⁹,Beeson James G¹²⁹^ORCID

Affiliation:

1. Burnet Institute, Melbourne

2. Department of Medicine, University of Melbourne, Parkville, Australia

3. Centre for Geographic Medicine - Coast, Kenya Medical Research Institute, Kilifi, Kenya

4. Department of Infectious Diseases, Parasitology, Universitätsklinikum Heidelberg, Germany

5. Institute for Glycomics, Griffith University, Southport

6. Walter and Eliza Hall Institute of Medical Research, Parkville

7. Department of Biochemistry and Genetics, La Trobe University, Melbourne

8. Clinical Tropical Medicine Laboratory, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston

9. Central Clinical School and Department of Microbiology, Monash University, Melbourne, Australia

Abstract

Human immunization with a polymorphic malaria vaccine candidate, MSP2, induced functional cross-reactive antibodies targeting conserved epitopes. This contrasts with naturally acquired antibodies, which target polymorphic epitopes, mediating immune escape. Findings reveal potential to overcome antigenic diversity for effective malaria vaccines.

Funder

National Health and Medical Research Council of Australia

Australian Research Council

Wellcome Trust

NHMRC

Victorian State Government

PATH Malaria Vaccine Initiative

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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