Declining Antibody Affinity Over Time After Human Vaccination With a <i>Plasmodium falciparum</i> Merozoite Vaccine Candidate-Reference-Cited by-同舟云学术

Declining Antibody Affinity Over Time After Human Vaccination With a Plasmodium falciparum Merozoite Vaccine Candidate

Published:2024-05-09 Issue: Volume: Page:
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Persson Kristina E M¹²,Horton Jessica L³,Kurtovic Liriye³,McCarthy James S⁴⁵,Anders Robin F⁶,Beeson James G³⁷⁸^ORCID

Affiliation:

1. Department of Laboratory Medicine, Lund University , Lund , Sweden

2. Department of Clinical Chemistry and Pharmacology, Laboratory Medicine, Region Skåne , Lund , Sweden

3. Burnet Institute , Melbourne, Victoria , Australia

4. QIMR-Berghofer Medical Research Institute , Queensland Australia

5. Victorian Infectious Diseases Services, Doherty Institute, University of Melbourne , Melbourne, Victoria , Australia

6. Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Sciences, La Trobe University , Bundoora, Victoria , Australia

7. Central Clinical School and Department of Microbiology, Monash University , Melbourne, Victoria , Australia

8. Department of Infectious Diseases, University of Melbourne , Melbourne, Victoria , Australia

Abstract

Abstract Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies. Clinical Trials Registration Australian New Zealand Clinical Trials Registry ACTRN12607000552482.

Funder

National Health and Medical Research Council

Avtal om Läkarutbildning och Forskning

Region Skåne

Lund University

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jid/advance-article-pdf/doi/10.1093/infdis/jiae259/58203120/jiae259.pdf

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