Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Tissue Metabolic Changes Drive Cytokine Responses to Mycobacterium tuberculosis

Published:2018-04-03 Issue:1 Volume:218 Page:165-170
ISSN:0022-1899
Container-title:The Journal of Infectious Diseases
language:en
Short-container-title:

Author:

Lachmandas Ekta¹,Rios-Miguel Ana B¹,Koeken Valerie A C M¹,van der Pasch Eva¹,Kumar Vinod¹²,Matzaraki Vasiliki²,Li Yang²,Oosting Marije¹,Joosten Leo A B¹,Notebaart Richard A¹³,Noursadeghi Mahdad⁴,Netea Mihai G¹,van Crevel Reinout¹,Pollara Gabriele⁴^ORCID

Affiliation:

1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen

2. University of Groningen, University Medical Center Groningen, The Netherlands

3. Laboratory of Food Microbiology, Wageningen University and Research, The Netherlands

4. Division of Infection and Immunity, University College London, United Kingdom

Abstract

Our study reveals that human tissue challenged with mycobacterial antigens induces differential expression of genes that regulate multiple metabolic pathways. We demonstrate that variable expression of these metabolic genes influences the cytokine response of immune cells stimulated by Mycobacterium tuberculosis.

Funder

Wellcome Trust

National Institute for Health Research Biomedical Research Centre

European Research Council

Netherlands Organization for Scientific Research

European Union’s Seventh Framework Programme

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

Link

http://academic.oup.com/jid/article-pdf/218/1/165/25091097/jiy173.pdf