Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease-Reference-Cited by-同舟云学术

Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease

Published:2021-05-05 Issue:592 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Pollara Gabriele¹^ORCID,Turner Carolin T.¹^ORCID,Rosenheim Joshua¹^ORCID,Chandran Aneesh¹^ORCID,Bell Lucy C. K.¹^ORCID,Khan Ayesha¹^ORCID,Patel Amit¹^ORCID,Peralta Luis Felipe²^ORCID,Folino Anna³^ORCID,Akarca Ayse¹^ORCID,Venturini Cristina¹^ORCID,Baker Tina¹,Ecker Simone¹^ORCID,Ricciardolo Fabio L. M.³^ORCID,Marafioti Teresa¹^ORCID,Ugarte-Gil Cesar²⁴^ORCID,Moore David A. J.⁴⁵^ORCID,Chain Benjamin M.¹^ORCID,Tomlinson Gillian S.¹^ORCID,Noursadeghi Mahdad¹^ORCID

Affiliation:

1. University College London, London, UK.

2. School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

3. Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

4. TB Centre, London School of Hygiene & Tropical Medicine, London, UK.

5. Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia, Lima, Peru.

Abstract

In vivo IL-17A activity is elevated in active tuberculosis and may be a therapeutic target to attenuate disease-associated immunopathology.

Funder

Wellcome

Medical Research Council

National Institute for Health Research