Effect of Rosuvastatin Therapy on Biomarkers of Inflammation and Immune Activation in People With Human Immunodeficiency Virus at Intermediate Cardiovascular Risk

Author:

Hearps Anna C12,Angelovich Thomas A13,Trevillyan Janine M2,Wong Michelle E14,Calmy Alexandra5,Hoy Jennifer F2,Jaworowski Anthony123

Affiliation:

1. Life Sciences Discipline, Burnet Institute, Melbourne, Victoria, Australia

2. Department of Infectious Diseases, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia

3. School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia

4. Central Clinical School, Monash University, Melbourne, Victoria, Australia

5. Division of Infectious Diseases, HIV/AIDS Unit, Geneva University Hospitals, Geneva, Switzerland

Abstract

Abstract Background Statins may help prevent cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH) with chronic inflammation owing to their pleotropic lipid-lowering and anti-inflammatory properties. Methods The impact of 48 weeks of rosuvastatin therapy on inflammation and immune activation in a double-blind, placebo-controlled trial in PWH at moderate cardiovascular disease risk was assessed. Results Rosuvastatin did not alter plasma levels of interleukin 6, soluble tumor necrosis factor receptor type 2, CXCL10, soluble CD14, or soluble vascular cellular adhesion molecule 1 (P ≥ .1 for all). Proportions of CD16+ monocyte subsets were increased in PWH receiving rosuvastatin. Conclusions The potential benefits of statin use in PWH with normal lipid levels requires further clinical outcome research.

Funder

National Health and Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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