Immune Biomarkers in the Prediction of Future Myocardial Infarctions in People With Human Immunodeficiency Virus

Author:

Trevillyan Janine M12,Moser Carlee3,Currier Judith S1,Sallam Tamer4

Affiliation:

1. Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles

2. Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Australia

3. Harvard T. H. Chan School of Public Health, Boston, Massachusetts

4. Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles

Abstract

Abstract In a retrospective case control analysis, following adjustments for high-sensitivity C-reactive protein (hsCRP), traditional cardiovascular risk factors, and the CD4/CD8 T-cell ratio, higher lipopolysaccharide-binding protein (LBP) was associated with future myocardial infarctions in hsCRP human immunodeficiency virus (HIV). LBP may be a marker of cardiovascular risk with utility in HIV.

Funder

University of California, Los Angeles Centre for Acquired Immunodeficiency Syndrome Research

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Acquired Immunodeficiency Syndrome Clinical Trials Group Specimen Repository Pilot

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference12 articles.

1. Cardiovascular risk assessment in HIV-infected male patients: a comparison of Framingham, SCORE, PROCAM and DAD risk equations;Pirš;Acta Dermatovenerol Alp Pannonica Adriat,2014

2. Characteristics, prevention, and management of cardiovascular disease in people living with HIV: a scientific statement from the American Heart Association;Feinstein;Circulation,2019

3. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis;Sallam;J Lipid Res,2014

4. Association of lipopolysaccharide-binding protein and coronary artery disease in men;Lepper;J Am Coll Cardiol,2007

5. Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection;Lichtfuss;Biomark Med,2011

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