Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection-Reference-Cited by-同舟云学术

Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection

Published:2011-04 Issue:2 Volume:5 Page:171-186
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Lichtfuss Gregor F¹²,Hoy Jennifer²³,Rajasuriar Reena¹²⁴,Kramski Marit⁵,Crowe Suzanne M¹²³,Lewin Sharon R

Affiliation:

1. Centre for Virology, Burnet Institute, Melbourne, Australia

2. Department of Medicine, Monash University, Melbourne, Australia

3. Infectious Diseases Unit, The Alfred Hospital, Melbourne, Australia

4. Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

5. Department of Microbiology & Immunology, University of Melbourne, Melbourne, Australia.

Abstract

Combination antiretroviral therapy (cART) has significantly reduced morbidity and mortality of HIV-infected patients, yet their life expectancy remains reduced compared with the general population. Most HIV-infected patients receiving cART have some persistent immune dysfunction characterized by chronic immune activation and premature aging of the immune system. Here we review biomarkers of T-cell activation (CD69, -25 and -38, HLA-DR, and soluble CD26 and -30); generalized immune activation (C-reactive protein, IL-6 and D-dimer); microbial translocation (lipopolysaccharide, 16S rDNA, lipopolysaccharide-binding protein and soluble CD14); and immune dysfunction of specific cellular subsets (T cells, natural killer cells and monocytes) in HIV-infected patients on cART and their relationship to adverse clinical outcomes including impaired CD4 T-cell recovery, as well as non-AIDS clinical events, such as cardiovascular disease.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm.11.15

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