Determinants of Gammaherpesvirus Shedding in Saliva Among Ugandan Children and Their Mothers

Author:

Newton Robert12,Labo Nazzarena3,Wakeham Katie14,Marshall Vickie3,Roshan Romin3,Nalwoga Angela15ORCID,Sebina Ismail6,Muhangi Lawrence15,Webb Emily L5,Miley Wendell3,Rochford Rosemary7,Elliott Alison M15,Whitby Denise3

Affiliation:

1. Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda

2. University of York, York

3. Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical Inc.–Frederick National Laboratory for Cancer Research, Maryland

4. Sussex Cancer Center, Brighton and Sussex University Hospitals, National Health Service Trust, Sussex

5. London School of Hygiene and Tropical Medicine, London, United Kingdom

6. Department of Immunology, University of Washington, Seattle

7. Department of Immunology and Microbiology, University of Colorado, Denver

Abstract

Among Ugandan mother-child pairs, Epstein-Barr virus was more likely to be shed in saliva than Kaposi sarcoma–associated virus. Child’s sex and parasitic infections influenced viral shedding. Shedding of each virus was inversely related, suggesting an interaction between them.

Funder

Intramural Program of the National Cancer Institute

National Institutes of Health

Department of Health and Human Services

Wellcome Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Immunology and Allergy

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