Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study-Reference-Cited by-同舟云学术

Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study

Published:2024-05-10 Issue: Volume: Page:
ISSN:0275-1879
Container-title:Special Care in Dentistry
language:en
Short-container-title:Special Care in Dentistry

Author:

Bueno Marinho Gabriella¹,Bertoldi Franco Juliana²^ORCID,Tenório Jefferson R.¹³^ORCID,Silva Andrade Natália¹⁴^ORCID,Zerbinati Rodrigo Melim⁵,Medina Janaína B.⁶^ORCID,Pérez‐Sayáns Mário⁶^ORCID,Braz‐Silva Paulo Henrique⁵⁷,Ortega Karem L.¹⁶⁷^ORCID

Affiliation:

1. Special Care Dentistry Centre (CAPE) Department of Stomatology of the University of São Paulo School of Dentistry São Paulo São Paulo Brazil

2. Division of Dentistry of the Clinics Hospital University of São Paulo School of Medicine São Paulo São Paulo Brazil

3. Department of Pathology and Oral Diagnosis Federal University of Rio de Janeiro School of Dentistry Rio de Janeiro Rio de Janeiro Brazil

4. Department of Dentistry Federal University of Sergipe Lagarto Sergipe Brazil

5. Laboratory of Virology Institute of Tropical Medicine of São Paulo University of São Paulo School of Medicine São Paulo São Paulo Brazil

6. Oral Medicine, Oral Surgery and Implantology Unit MedOralRes Group University of Santiago de Compostela Health Research Institute of Santiago de Compostela (IDIS) A Coruña Spain

7. Department of Stomatology University of São Paulo School of Dentistry São Paulo São Paulo Brazil

Abstract

AbstractAimsThe objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic‐cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross‐sectional study.Methods and resultsSpecimens of plasma and saliva from 72 cirrhotic individuals were analyzed by means of polymerase chain reaction. The patient population had a mean age of 54.84 years old (SD ± 10) and was 70% males (51/72). Approximately 47% (n = 34) of the patients had leukopenia and HHV was not identified in the plasma specimens. The main species of HHV identified in the saliva were HHV‐7 (n = 42, 62%) and Epstein‐Barr virus (EBV) (n = 30, 41%). Moreover, there was a significant decrease in the total number of leukocytes and lymphocytes in saliva containing EBV (P = .038 and P = .047, respectively).ConclusionThe results show that the presence of EBV in the saliva of cirrhotic patients was correlated with their circulating immune status. It may be possible that the immune dysfunction displayed by the cirrhotic patients plays a role in the shedding of EBV into saliva.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/scd.13016

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